منابع مشابه
Cloning and expression analysis of two ROR-γ homologues (ROR-γa1 and ROR-γa2) in rainbow trout Oncorhynchus mykiss.
This paper describes the cloning and characterisation of two retinoid-related orphan receptor (ROR)-γ homologues (ROR-γa1 and -γa2) in rainbow trout (Oncorhynchus mykiss). The coding region predicted for both homologues consists of 1410 base pairs (bp), which translate into two 469 amino acid (aa) proteins. The trout ROR-γs revealed a high conservation of both DNA- and ligand-binding domains (f...
متن کاملPharmacologic Inhibition of ROR
IL-17–producing CD4 + Th17 cells, CD8 + Tc17 cells, and gd T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORgt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel, potent, and selective RORgt inverse agonist (TMP778), and its inactive diastereomer (TMP776). This chemistry, for the first time to our knowledge,...
متن کاملA Rhythmic Ror
The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and ...
متن کاملROR: Rejection of Outliers by Rotations
ÐWe address the problem of rejecting false matches of points between two perspective views. The two views are taken from two arbitrary, unknown positions and orientations. Even the best algorithms for image matching make some mistakes and output some false matches. We present an algorithm for identification of the false matches between the views. The algorithm exploits the possibility of rotati...
متن کاملRolling ribbons.
We present the results of a combined experimental and theoretical investigation of rolling elastic ribbons. Particular attention is given to characterizing the steady shapes that arise in static and dynamic rolling configurations. In both cases, above a critical value of the forcing (either gravitational or centrifugal), the ribbon assumes a two-lobed, peanut shape similar to that assumed by ro...
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ژورنال
عنوان ژورنال: BMJ Supportive & Palliative Care
سال: 2011
ISSN: 2045-435X,2045-4368
DOI: 10.1136/bmjspcare-2011-000105.87